![]() ![]() Results showed that across all 3 subgroups, mean change from baseline to final levodopa dose was similar, and amantadine use decreased from approximately 30% at baseline to approximately 10% during the study. ![]() ![]() Of the 354 patients enrolled in the study, 196 (69%) had no baseline tremor, 38 (13%) had mild baseline tremor, and 52 (18%) had significant baseline tremor. Patients recorded “on” and “off” time with troublesome dyskinesia using the Parkinson’s Disease Symptom Diary. “Efficacy and safety were evaluated in the context of these 3 baseline tremor subgroups.” “The Unified Parkinson’s Disease Rating Scale (UPDRS) Part III Question 20 (resting tremor) total score (5 categories: arms, legs, and face) was used to stratify patients into 3 subgroups defined by their maximum baseline tremor score,” he noted. Following a screening period, during which patients were converted to and stabilized on oral levodopa monotherapy, a PEG-J tube was surgically placed. Fernandez and colleagues evaluated the effect of levodopa-carbidopa intestinal gel administered via a percutaneous endoscopic gastrojejunostomy (PEG-J) tube in a Phase 3, 12-month open-label study. ![]() Although typically treated with dopaminergic or agents such as amantadine, “the resting tremor response to dopaminergic therapy is often regarded as insufficient and underpins one of the reasons why deep brain stimulation, which requires an invasive procedure, may be chosen over other non-oral therapies in advanced Parkinson’s disease,” he stated.ĭr. In patients with advanced Parkinson’s disease, 70% to 100% report resting tremor. “Levodopa-carbidopa intestinal gel may alleviate resting tremor that was not well controlled by optimized oral medication in patients with advanced Parkinson’s disease,” noted lead study author Hubert Fernandez, MD, of the Center for Neurological Restoration, Cleveland Clinic, Cleveland, OH. VANCOUVER, BC-Patients with advanced Parkinson’s disease had resting tremors improved with levodopa-carbidopa intestinal gel, a study presented at the 68 th Annual AAN Meeting has found. ![]()
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